Publications

Pubmed

2019

Han, G., A. Havnaer, H. H. Lee, D. Carmichael†, and L. R. Martinez. 2019. Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis. Clin Immunol. In Press.

Lee, H. H., J. Del Pozzo†, S. A. Salamanca†, H. Hernandez*, and L. R. Martinez. 2019. Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification. Fungal Genet Biol. 132:103258.

Di Caro†, D., H. H. Lee, C. Belisario†, R. L. Ramos, and L. R. Martinez. 2019. Combination of acute intravenous methamphetamine injection and LPS challenge facilitate leukocyte infiltration into the central nervous system of C57BL/6 mice. Int Immunopharmacol. 75:105751.

Hernandez*, H., V. H. Erives*, and L. R. Martinez. 2019. Coccidiodomycosis: Epidemiology, Fungal Pathogenesis, and Therapeutic Development. Curr Trop Med Rep. 6:132.

2018

Aslanyan†, L., H. H. Lee, V. V. Ekhar†, R. L. Ramos, and L. R. Martinez. 2018. Methamphetamine impairs IgG1-mediated phagocytosis and killing of Cryptococcus neoformans by J774.16 macrophage- and NR-9640-microglia-like cells. Infect Immun. 87 (2): pii: e00113-18.

Sanchez, D. A. and L. R. Martinez. 2018. Underscoring inter-strain variability and the impact of growth conditions on associated antimicrobial susceptibilities in pre-clinical testing of novel antimicrobial drugs. Crit Rev Microbiol. 6:1-14.

Guimaraes, A. J., M. Duarte de Cerqueira, D. Zamith-Miranda, P. H. Lopez, M. L. Rodrigues, B. Pontes, N. B. Viana, C. M. DeLeon-Rodriguez, D. C. Pereira Rossi, A. Casadevall, A. M. Gomes, L. R. Martinez, R. L. Schnaar, J. D. Nosanchuk, and L. Nimrichter. 2018. Host membrane glycosphingolipids and lipid microdomains facilitate Histoplasma capsulatum internalization by macrophages. Cell Microbiol. 14:e12976.

Gwin, C. M., N. Prakash, J. C. Belisario, L. Haider, M. L. Rosen, L. R. Martinez, and N. W. Rigel. 2018. The apolipoprotein N-acyl transferase Lnt is dispensable for growth in Acinetobacter species. Microbiology. 164:1547-1556.

Martinez, L. R., D. W. Boucaud, A. Casadevall, and A. August. 2018. Factors Contributing to the Success of NIH-Designated Underrepresented Minorities in Academic and Nonacademic Research Positions. CBE-Life Sci Educ. 17:ar32.

Hernandez*, H. and L. R. Martinez. 2018. Relationship of environmental disturbances and the infectious potential of fungi. Microbiology. 16:233-241.

2017

Ramos, R. L., E. Guercio, and L. R. Martinez. 2017. Pre-medical preparation in microbiology among applicants and matriculants in osteopathic medical school in the United States. J Microbiol Biol Educ. 18:1.

Ramos, R. L., K. Alviña, and L. R. Martinez. 2017. Diversity of graduates from bachelor’s, master’s, and doctoral degree neuroscience programs in the United States. J Undergrad Neurosci Educ. 16: A6-A13.

Aslanyan†, L., V. V. Ekhar†, C. M. DeLeon-Rodriguez, and L. R. Martinez. 2017. Capsular specific IgM enhances complement-mediated phagocytosis and killing of Cryptococcus neoformans by methamphetamine-treated J774.16 macrophage-like cells. Int Immunopharmacol. 49:77-84.

Zhang, L., C. Wiles†, L. R. Martinez, and G. Han. 2017. Neutrophil to lymphocyte ratio decreases after treatment of psoriasis with therapeutic antibodies. J Euro Acad Dermatol Venereol. 31:e491-e492.

Aslanyan†, L., D. A. Sanchez, S. Valdebenito, E. A. Eugenin, R. L. Ramos, and L. R. Martinez. 2017. The crucial role of biofilms in Cryptococcus neoformans survival within macrophages and colonization of the central nervous system. J. Fungi. 3:10.

2016

Koutsouras†, G. W., R. L. Ramos, and L. R. Martinez. 2016. Role of microglia in fungal infections of the central nervous system. Virulence. 18:1-14.

Mihu, M. R., V. Cabral, R. Pattabhi, M. T. Tar, K. P. Davies, A. J. Friedman,  L. R. Martinez, and J. D. Nosanchuk. 2016. Sustained nitric oxide releasing nanoparticles interfere with methicillin-resistant Staphylococcus aureus adhesion and biofilm formation in a rodent central venous catheter model. Antimicrob Agents Chemother. 61: e02020-16.

Delfiner†, M. S., L. R. Martinez, and C. S. Pavia. 2016. A Gram stain hands-on workshop enhances first year medical students’ technique competency in comprehension and memorization. PLoS One. 11:e0163658.

Castellano, P., C. Nwagbo, L. R. Martinez, and E. A. Eugenin. 2016. Methamphetamine compromises gap junctional communication in astrocytes and neurons. J Neurochem. 137:561-75.

Cordero, R. J., S. C. Liedke, G. De Souza-Araujo, L. R. Martinez, L. Nimrichter, S. Frases, J. M. Peralta, A. Casadevall, M. L. Rodrigues, J. D. Nosanchuk, and A. J. Guimaraes. 2016. Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection. Sci Rep. 6:21765.

Ahmadi*, M., H. H. Lee†, D. A. Sanchez*, A. J. Friedman, M. T. Tar, K. P. Davies, J. D. Nosanchuk, and L. R. Martinez. 2016. Sustained nitric oxide releasing nanoparticles induce cell death in Candida albicans yeast and hyphal cells preventing biofilm formation in vitro and in a rodent central venous catheter model. Antimicrob Agents Chemother. 60:2185-2194. {Article featured in the website Nanowerk. http://www.nanowerk.com/nanotechnology-news/newsid=42433.php}

Shah†, H., and L. R. Martinez. 2016. Current approaches to implement citizen science in the classroom. J Microbiol Biol Educ. 17:17-22.

2015

Krishnamoorthy†, S., Shah†, B. P., Lee†, H. H., and L. R. Martinez. 2015. Microbicides alter the expression and function of RND-type efflux pump AdeABC in biofilm-associated cells of Acinetobacter baumannii clinical isolates. Antimicrob Agents Chemother. 60:57-63.

Radu, M. R., J. Roman-Sosa, A. K. Varshney, E. A. Eugenin, B. P. Shah†, H. H. Lee†, L. N. Nguyen, A. J. Guimaraes, B. C. Fries, J. D. Nosanchuk, and L. R. Martinez. 2015. Methamphetamine alters the antimicrobial efficacy of phagocytic cells during methicillin-resistant Staphylococcus aureus skin infections. mBio. 6:e01622-15. {Article featured in ASM’s mBiosphere blog, http://mbioblog.asm.org/mbiosphere/2015/11/yet-another-reason-to-avoid-methamphentamine-negative-effects-of-meth-on-wound-healing.html; Editor’s pick}

Grguric-Smith*, L. M., H. H. Lee†, J. A. Gandhi†, M. B. Brennan†, C. M. DeLeon-Rodriguez, C. Coelho, G. Han, and L. R. Martinez. 2015. Neutropenia exacerbates infection by Acinetobacter baumannii clinical isolates in a murine wound model. Frontier Microbiol. 6:1134.

Martinez, L. R. 2015. Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development. Front. Microbiol. 6:1112. {Expert commentary; invited}

Abdulkareem†, A. F., H. H. Lee†, M. Ahmadi*, and L. R. Martinez. 2015. Fungal serotype-specific differences in bacterial-yeast interactions. Virulence. 6:654-9. {Highlighted commentary on article in Virulence. 6:677-678}

Martinez, L. R. and A. Casadevall. 2015. Biofilm Formation by Cryptococcus neoformans. Microbiol Spectrum. 3 (3):MB-0006-2014.

Salamanca†, S. A., E. E. Sorrentino†, J. D. Nosanchuk, and  L. R. Martinez. 2015. Impact of methamphetamine in infection and immunity. Front Neurosc. 8:445.

2014

Parisi†, D. N. and  L. R. Martinez. 2014. Intracellular Haemophilus influenzaeinvades the brain: Is zyxin a critical blood brain barrier component regulated by TNF-alpha? Virulence. 5:645-647. {Expert commentary; invited}

Gandhi†, J. A., V. V. Ekhar†, M. B. Asplund†, A. F. Abdulkareem†, M. Ahmadi*, C. Coelho, and L. R. Martinez. 2014. Alcohol enhances Acinetobacter baumannii-associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection. PLoS One. 9 (4):e95707.

Tar, M. T., L. R. Martinez, J. D. Nosanchuk, and K. P. Davies. 2014. The effect of methamphetamine on an animal model of erectile function. Andrology. 2:531-536.

2013

Orsinger-Jacobsen*, S. J., S. S. Patel†, E. M. Vellozzi, P. Gialanella, L. Nimrichter, K. Miranda, and L. R. Martinez. 2013. Use of a stainless steel washer platform to study Acinetobacter baumannii adhesion and biofilm formation on abiotic surfaces. Microbiology. 159:2594-2604. {Images from the article were selected for the cover of the issue}

Manepalli†, S., J. A. Gandhi†, V. V. Ekhar†, M. B. Asplund†, C. Coelho, and L. R. Martinez. 2013. Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesis. J Med Microbiol. 62:1747-1754.

Varshney, A. K., X. Wang, M. D. Scharff, J. MacIntyre, R. S. Zollner, O. V. Kovalenko, L. R. Martinez, F. R. Byrne, and B. C. Fries. 2013. Staphylococcal enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections.  J Infect Dis. 208:2058-2066.

Patel†, D., G. M. Desai†, S. Frases, R. J. Cordero, C. M. DeLeon-Rodriguez, E. A. Eugenin, J. D. Nosanchuk, and  L. R. Martinez. 2013. Methamphetamine enhances Cryptococcus neoformanspulmonary infection and dissemination to the brain. MBio. 4:e00400-13. {Article featured in The Los Angeles Times. http://www.latimes.com/news/science/sciencenow/la-sci-sn-meth-lung-infection-20130730,0,2202905.story; Editor’s pick}

Asplund†, M. B., C. Coelho, R. J. Cordero, and  L. R. Martinez. 2013. Alcohol impairs J774.16 macrophage-like cell antimicrobial functions in Acinetobacter baumannii infection. Virulence. 4:467-472. {Highlighted commentary on article in Virulence. 4:435-436}

Eugenin, E. A., J. M. Greco*, S. Frases, J. D. Nosanchuk, and L. R. Martinez. 2013. Methamphetamine Alters Blood Brain Barrier Protein Expression Facilitating Central Nervous System Infection by Neurotropic Cryptococcus neoformans. J Infect Dis. 208: 699-704. {Images from the article were selected for the cover of the issue}

Peerzada†, H., J. A. Gandhi†, A. J. Guimaraes, J. D. Nosanchuk, and L. R. Martinez. 2013. Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues. Immunobiology. 218:1063-1068.

2012

Martinez, L. R. 2012. Nitric Oxide Releasing Nanoparticles: Challenges and Future Prospects of Therapeutic Delivery. Ther Deliv. 3:1139-1142. {Expert commentary; invited}

Nicola, A. M., P. Albuquerque, L. R. Martinez, R. A. Dal-Rosso, C. Saylor, M. De Jesus, J. D. Nosanchuk, and A. Casadevall. 2012. Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans. Infect Immun. 80:3065-3076.

Macherla†, C., D. A. Sanchez, M. Ahmadi*, E. M. Vellozzi, A. J. Friedman, J. D. Nosanchuk, and L. R. Martinez. 2012. Nitric oxide releasing nanoparticles for treatment of Candida albicans burn infections. Front Microbiol. 3:193.

Blecher, K., L. R. Martinez, C. Tuckman-Vernon, P. Nacharaju, D. Schairer, J. Chouake, J. M. Friedman, A. Alfieri, C. Guha, J. D. Nosanchuk, and A. J. Friedman. 2012. Nitric oxide releasing nanoparticles accelerate wound healing in NOD-SCID mice. Nanomedicine. 8:1364-1371.

Han, G., L. N. Nguyen, C. Macherla, Y. Chi, J. M. Friedman, J. D. Nosanchuk, and L. R. Martinez. 2012. Nitric oxide releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am J Pathol. 180:1465-73.

Schairer, D., L. R. Martinez, K. Blecher, J. Chouake, P. Nacharaju, P. Gialanella, J. M. Friedman, J. D. Nosanchuk, and A. J. Friedman. 2012. Nitric oxide nanoparticles: Pre-clinical utility as a therapeutic for intramuscular abscesses. Virulence. 3:62-67.

2011

Silva, F., D. Rossi, L. R. Martinez, S. Frases, F. Fonseca, C. Campos, M. Rodrigues, J. D. Nosanchuk, and S. Daffre. 2011. Effects of microplusin, a copper-chelating antimicrobial peptide, against Cryptococcus neoformans. FEMS Microbiol Lett. 324:64-72.

Cordero, R. J., B. Pontes, A. J. Guimaräes, L. R. Martinez, J. Rivera, B. C. Fries, L. Nimrichter, M. L. Rodrigues, N. B. Viana, and A. Casadevall. 2011. Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans. Infect Immun. 79:4990-5000.

Friedman, A. J., K. Blecher, D. Schairer, C. Tuckman-Vernon, P. Nacharaju, D. Sanchez, P. Gialanella, L. R. Martinez, J. M. Friedman, and J. D. Nosanchuk. 2011. Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. Nitric Oxide. 25:381-386

Friedman, A. J., K. Blecher, D. Sanchez, C. Tuckman-Vernon, P. Gialanella, J. M. Friedman, L. R. Martinez, and J. D. Nosanchuk. 2011. Susceptibility of Gram Positive and Negative Bacteria to Novel Nitric Oxide-Releasing Nanoparticle Technology. Virulence. 2:217-221.

Nguyen, L. N., D. Trofa, B. Kadereit, Z. Hamari, M. Agovino, L. R. Martinez, A. Gacser, D. L. Silver, and J. D. Nosanchuk. 2011. Candida parapsilosis Fat storage-Inducing Transmembrane (FIT) protein 2 Regulates Lipid Droplet Formation and Impacts Virulence. Microbes Infect. 13: 663-672.

Prados-Rosales, R., A. Baena, L. R. Martinez, J. Luque-Garcia, R. Kalscheuer, U. Veeraraghavan, C. Camara, J. D. Nosanchuk, G. S. Besra, B. Chen, J. Jimenez, A. Glatman-Freedman, W. R. Jacobs Jr, S. A. Porcelli, and A. Casadevall. 2011. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2 dependent-manner in mice. J Clin Invest.  121:1471-83.

Mihu, M. R. and L. R. Martinez. 2011. Novel therapies for treatment of multi-drug resistant Acinetobacter baumannii skin infections. Virulence. 2:97-102. {Invited review}

Guimarães, A. J., L. R. Martinez, and J. D. Nosanchuk. 2011. Passive administration of monoclonal antibodies against fungal pathogens. J Vis Exp. 48:2532.

2010

Martinez, L. R. and B. C. Fries. 2010. Fungal biofilms: relevance in the setting of human disease. Curr Fungal Infect Rep. 4:266-275. {Invited review}

Lopes, L.C., R. Rollin-Pinheiro, A. J. Guimarães, V. C. Bittencourt, L. R. Martinez, W. Koba, S. E. Farias, J. D. Nosanchuk, and E. Barreto-Bergter. 2010. Monoclonal antibodies against peptidorhamnomannans of Scedosporium apiospermum enhance the pathogenicity of the fungus. PLoS Negl Trop Dis. 4(10):e853.

Martinez, L. R., M. R. Mihu, M. Tar, R. J. Cordero, G. Han, A. J. Friedman, J. M. Friedman, and J. D. Nosanchuk. 2010. Anti-biofilm and antifungal efficacy of chitosan against candidal biofilms using an in vivo central venous catheter model. J Infect Dis. 201:1436-40. {Images from the article were selected for the cover of the issue}

Varshney, A. K., L. R. Martinez, S. M. Hamilton, A. E. Bryant, M. H. Levi, P. Gialanella, D. L. Stevens, and B. C. Fries. 2010. Augmented production of Panton Valentine Leukocidin toxin in methicillin resistant and sensitive Staphylococcus aureus is associated with worse outcome in murine skin infection model. J Infect Dis. 201:92-6.

Mihu, M. R., U. Sandkovsky, G. Han, J. M.  Friedman, J. D. Nosanchuk, and L. R. Martinez. 2010. The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections. Virulence. 1:62-7. {Highlighted commentary on article in Virulence. 1:6-7}

Martinez, L. R., M. R. Mihu, G. Han, S. Frases, R. J. Cordero, A. Casadevall, A. J. Friedman, J. M. Friedman, and J. D. Nosanchuk. 2010. The use of chitosan to damage Cryptococcus neoformans Biomaterials. 31:669-79.

2009

Han, G., L. R. Martinez, M. R. Mihu, A. J. Friedman, J. M. Friedman, and J. D. Nosanchuk. 2009. Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses. PLoS One. 4(11):e7804.

Martinez, L. R., G. Han, M. Chacko, M. R. Mihu, M. Jacobson, P. Gialanella, A. J. Friedman, J. D. Nosanchuk, and J. M. Friedman. 2009. Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J Invest Dermatol. 129:2463-9. {Highlighted commentary on article in J Invest Dermatol. 2009 Oct;129(10):2335-7}

Martinez, L. R., R. Mihu, A. Gacser, L. Santambrogio, and J. D. Nosanchuk. 2009. Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis. 200:131-41. {Images from the article were selected for the cover of the issue}.

2008

Martinez, L. R., C. Ibom*, A. Casadevall, and B. C. Fries. 2008. Characterization of phenotypic switching in Cryptococcus neoformans biofilms. Mycopathologia. 166:175-80

2007

Martinez, L. R., Ntiamoah, A. Gacser, A. Casadevall, and J. D. Nosanchuk. 2007. Voriconazole inhibits melanization in Cryptococcus neoformans. Antimicrob Agents Chemother. 51:4396-400.

Martinez, L. R., Ntiamoah, A. Casadevall, and J. D. Nosanchuk. 2007. Caspofungin reduces the incidence of fungal contamination in cell culture. Mycopathologia.  164:279-86.

2006

Martinez, L. R. and A. Casadevall. 2006. Cryptococcus neoformans biofilm formation depends on surface support and carbon source and reduces fungal cell susceptibility to heat, cold, and UV light. Appl Environ Microbiol. 73:4592-601.

Martinez, L. R., and A. Casadevall. 2006. Cryptococcus neoformans cells in biofilms are less susceptible to antimicrobial molecules produced by the innate immune system. Infect Immun. 74:6118-23.

Martinez, L. R., Christaki, and A. Casadevall. 2006. Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal action against cryptococcal biofilms in vitro. J Infect Dis. 194:261-66.

Martinez, L. R., A. Bryan, C. Apostolidis, A. Morgenstern, A. Casadevall, and E. Dadachova. 2006. Antibody-guided alpha-radiation effectively damages fungal biofilms. Antimicrob Agents Chemother. 50:2132-36.

Martinez, L. R. and A. Casadevall. 2006. Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro. Antimicrob Agents Chemother. 50:1021-33.

2005

Martinez, L. R., and A. Casadevall. 2005. Specific antibody can prevent fungal biofilm formation and this effect correlates with protective efficacy. Infect Immun. 73:6350-62.

2004

Martinez, L. R., Moussai, and A. Casadevall. 2004. Antibody to Cryptococcus neoformans glucurunoxylomannan inhibits the release of capsular antigen.  Infect Immun. 72:3674-9.

2001

Martinez, L. R., Garcia-Rivera, and A. Casadevall. 2001. Differences in the thermal susceptibility of Cryptococcus neoformans serotypes A (var. grubii) and D (var. neoformans) strains. J Clin Microb. 39:3365-7.

 

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